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Volume 5 | No. 10 | October 2016


Commentary
Cellular Star Trek: A laser-based shuttle transfers mitochondria into cells Guy Las, Orian Shirihai

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Original Research Article
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors Pablo J. Enriori, Weiyi Chen, Maria C. Garcia-Rudaz, Bernadette E. Grayson, Anne E. Evans, Sarah M. Comstock, Ursel Gebhardt, Hermann L. Müller, Thomas Reinehr, Belinda A. Henry, Russell D. Brown, Clinton R. Bruce, Stephanie E. Simonds, Sara A. Litwak, Sean L. McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H. Tschöp, Matthew J. Watt, Iain J. Clarke, Christian L. Roth, Kevin L. Grove, Michael A. Cowley

Abstract | Graphical abstract | PDF



Original Research Article
Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neuronsAmmy M. Santiago, Deborah J. Clegg, Vanessa H. Routh

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Original Research Article
The satiating hormone amylin enhances neurogenesis in the area postrema of adult ratsClaudia G. Liberini, Tito Borner, Christina N. Boyle, Thomas A. Lutz

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Original Research Article
Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of pubertyMaria Manfredi-Lozano, Juan Roa, Francisco Ruiz-Pino, Richard Piet, David Garcia-Galiano, Rafael Pineda, Aurora Zamora, Silvia Leon, Miguel A. Sanchez-Garrido, Antonio Romero-Ruiz, Carlos Dieguez, Maria Jesus Vazquez, Allan E. Herbison, Leonor Pinilla, Manuel Tena-Sempere

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Original Research Article
Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic controlSoledad Pitra, Yumei Feng, Javier E. Stern

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Original Research Article
Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesityKavaljit H. Chhabra, Jessica M. Adams, Graham L. Jones, Miho Yamashita, Martin Schlapschy, Arne Skerra, Marcelo Rubinstein, Malcolm J. Low

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Original Research Article
Adiponectin potentiates the acute effects of leptin in arcuate Pomc neuronsJia Sun, Yong Gao, Ting Yao, Yiru Huang, Zhenyan He, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hongbo Guo, Jianqun Yan, Yongsheng Chang, Hong Chen, Philipp E. Scherer, Tiemin Liu, Kevin W. Williams

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Original Research Article
Physiological role for leptin in the control of thermal conductanceKarl J. Kaiyala, Kayoko Ogimoto, Jarrell T. Nelson, Kenjiro Muta, Gregory J. Morton

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Original Research Article
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathwaySarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin, Haifei Xu, Glen Ernst, James C. Barrow, Baoji Xu, Michael D. Cameron, Theodore M. Kamenecka, Anutosh Chakraborty

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Original Research Article
Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profilingLoic Yengo, Abdelilah Arredouani, Michel Marre, Ronan Roussel, Martine Vaxillaire, Mario Falchi, Abdelali Haoudi, Jean Tichet, The D.E.S.I.R Study Group, Beverley Balkau, Amélie Bonnefond, Philippe Froguel

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Original Research Article
Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolismCarles Lerin, Allison B. Goldfine, Tanner Boes, Manway Liu, Simon Kasif, Jonathan M. Dreyfuss, Ana Luisa De Sousa-Coelho, Grace Daher, Irini Manoli, Justin R. Sysol, Elvira Isganaitis, Niels Jessen, Laurie J. Goodyear, Kirk Beebe, Walt Gall, Charles P. Venditti, Mary-Elizabeth Patti

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Original Research Article
Depot specific differences in the adipogenic potential of precursors are mediated by collagenous extracellular matrix and Flotillin 2 dependent signalingGerald Grandl, Sebastian Müller, Hansjörg Moest, Caroline Moser, Bernd Wollscheid, Christian Wolfrum

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Original Research Article
Genetic backgrounds determine brown remodeling of white fat in rodentsGiulia Ferrannini, Maria Namwanje, Bin Fang, Manashree Damle, Dylan Li, Qiongming Liu, Mitchell A. Lazar, Li Qiang

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Original Research Article
Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weightZulaykho Shamansurova, Paul Tan, Basma Ahmed, Emilie Pepin, Ondrej Seda, Julie L. Lavoie

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Original Research Article
Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopeniaHejiao Bian, Jean Z. Lin, Chendi Li, Stephen R. Farmer

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Original Research Article
Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretionMahmoud El Azzouny, Melissa J. Longacre, Israr-ul H. Ansari, Robert T. Kennedy, Charles F. Burant, Michael J. MacDonald

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Original Research Article
The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human isletsKevin Vivot, Valentine S. Moullé, Bader Zarrouki, Caroline Tremblay, Arturo D. Mancini, Hasna Maachi, Julien Ghislain, Vincent Poitout

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Original Research Article
Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammationCyrielle Billon, Sadichha Sitaula, Thomas P. Burris

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Original Research Article
Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient miceChristopher D. Morrison, Zheng Hao, Michael B. Mumphrey, R. Leigh Townsend, Heike Münzberg, Jianping Ye, Hans-Rudolf Berthoud

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Original Research Article
Fibroblast activation protein (FAP) as a novel metabolic targetMiguel Angel Sánchez-Garrido, Kirk M. Habegger, Christoffer Clemmensen, Cassie Holleman, Timo D. Müller, Diego Perez-Tilve, Pengyun Li, Archita S. Agrawal, Brian Finan, Daniel J. Drucker, Matthias H. Tschöp, Richard D. DiMarchi, Alexei Kharitonenkov

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Brief Communication
Sex differences in obesity development in pair-fed neuronal lipoprotein lipase deficient miceHong Wang, Yongping Wang, Matthew D. Taussig, Robert H. Eckel

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Brief Communication
Dynamic DNA methylation landscape defines brown and white cell specificity during adipogenesisYen Ching Lim, Sook Yoong Chia, Shengnan Jin, Weiping Han, Chunming Ding, Lei Sun

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Brief Communication
Osteocalcin is necessary and sufficient to maintain muscle mass in older micePaula Mera, Kathrin Laue, Jianwen Wei, Julian Meyer Berger, Gerard Karsenty

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Brief Communication
The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respirationLinda A. Villani, Brennan K. Smith, Katarina Marcinko, Rebecca J. Ford, Lindsay A. Broadfield, Alex E. Green, Vanessa P. Houde, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg

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Maria Namwanje
Columbia University, New York, USA
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