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Volume 4 | No. 4 | April 2015


Original Research Article
Clic4, a novel protein that sensitizes β-cells to apoptosisDhaval Patel, Damien Ythier, Flora Brozzi, Decio L. Eizirik, Bernard Thorens

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Original Research Article
Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase ASindhu Rajan, Lorna M. Dickson, Elizabeth Mathew, Caitlin M.O. Orr, Johanne H. Ellenbroek, Louis H. Philipson, Barton Wicksteed

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Original Research Article
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemiaGao Sun, Gabriela da Silva Xavier, Tracy Gorman, Claire Priest, Antonia Solomou, David J. Hodson, Marc Foretz, Benoit Viollet, Pedro-Luis Herrera, Helen Parker, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne, Christophe Magnan, Anna Marley, Guy A. Rutter

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Original Research Article
FTO is necessary for the induction of leptin resistance by high-fat feedingY.C. Loraine Tung, Pawan Gulati, Che-Hsiung Liu, Debra Rimmington, Rowena Dennis, Marcella Ma, Vladimir Saudek, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo

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Original Research Article
TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neuronsMargaret B. Allison, Christa M. Patterson, Michael J. Krashes, Bradford B. Lowell, Martin G. Myers, David P. Olson

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Original Research Article
Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistanceSu Gao, Ryan P. McMillan, Qingzhang Zhu, Gary D. Lopaschuk, Matthew W. Hulver, Andrew A. Butler

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Original Research Article
Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout miceJanine Krüger, Sebastian Brachs, Manuela Trappiel, Ulrich Kintscher, Heike Meyborg, Ernst Wellnhofer, Christa Thöne-Reineke, Philipp Stawowy, Arne Östman, Andreas L. Birkenfeld, Frank D. Böhmer, Kai Kappert

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Brief communication
Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesisColin N. Young, Donald A. Morgan, Scott D. Butler, Kamal Rahmouni, Susan B. Gurley, Thomas M. Coffman, Allyn L. Mark, Robin L. Davisson

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Brief communication
The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasisWeijuan Shao, Xiaoquan Xiong, Wilfred Ip, Fenghao Xu, Zhuolun Song, Kejing Zeng, Marcela Hernandez, Tao Liang, Jianping Weng, Herbert Gaisano, M. Cristina Nostro, Tianru Jin

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Brief communication
The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitisKristine Griffett, Ryan D. Welch, Colin A. Flaveny, Grant R. Kolar, Brent A. Neuschwander-Tetri, Thomas P. Burris

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Editorial Board and credits


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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

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Andrew A. Butler
Saint Louis University School of Medicine
Referring article

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Conferences & Events
September
19 - 21
2015
Helmholtz-Nature Medicine Diabetes Conference
Munich, Germany
Supported by
Helmholtz Zentrum München
Deutsches Forschungszentrum
f. Gesundheit und Umwelt GmbH
The German Center for
Diabetes Research (DZD)