Eating disorders (EDs) are damaging mental and metabolic illnesses. Recent evidence suggests that epigenetic mechanisms may be involved in initiating and maintaining EDs. Schroeder et al. explored the effects of chronic variable stress during the whole period of gestation, response to food restriction, and susceptibility to develop activity based-anorexia, binge eating, and metabolic syndrome in male and female offspring. They report that chronic prenatal stress induces sexually dimorphic effects on placental function, affecting fetal hypothalamic programming and subsequent basal metabolism and the response to a variety of metabolic challenges.