miRNAs are small non-coding RNAs that regulate the expression of target genes by inhibiting translation or by inducing mRNA degradation. Several studies have illustrated the importance of miRNAs in glucose homeostasis. Dusaulcy et al. hypothesized that miRNAs are involved in alpha-cell molecular and functional alterations or adaptations in type 2 diabetes. They identified 16 miRNAs in alpha-cells and 28 in beta-cells differentially regulated according to diet. The most highly differentially regulated miRNA in alpha-cells from hyperglycemic mice, miR-132-3p, was found to be involved in alpha-cell proliferation and survival.