Brown adipose tissue (BAT) thermogenesis increases with prolonged exposure to cold, enabling mammals to maintain core body temperature. There is evidence to suggest direct cold-sensing by brown adipocytes via transient receptor potential melastatin 8 (TRPM8). Phosphoinositide interacting regulator of TRPs (Pirt) is an endogenous regulator of TRP channels. Jall and colleagues report that Pirt deficient female mice have an increased body weight and impaired glucose tolerance. This increased susceptibility to develop obesity and glucose intolerance is abrogated in the presence of a high-fat, high-sugar diet. Also, the authors reveal that Pirt is dispensable for TRPM8-induced BAT thermogenesis in vivo.