Aging is a negative regulator of brown adipose tissue (BAT) formation and function. There is evidence that the effects of various lipid species on adipose tissue play a central role in the emergence of metabolic pathologies. However, very little is known about age-related changes of lipid metabolites in BAT, their involvement in BAT dysfunction and the contribution of this process to metabolic disorders. To identify functional lipid biomarkers of brown adipose tissue aging, Gohlke et al. combined metabolomic and proteomic analyses. These revealed that changes of several lipid classes and individual metabolite species correlate with adipose tissue aging. Among these, sphingolipids are significantly induced in aged BAT.