White adipose tissue (WAT) expands by increasing adipocyte number (hyperplasia) and size (hypertrophy). Their relative importance differs between individuals resulting in alternate adipose morphologies. Hypertrophic WAT is the pernicious morphology, which is associated with dyslipidemia, insulin resistance, and T2D. Kerr and colleagues tested whether WAT morphology is epigenetically regulated and performed CpG-methylome profiling on abdominal subcutaneous adipocytes from a large cohort of women. Their results support the notion that differential CpG-methylation in adipocytes is linked to hypertrophic WAT morphology predisposing to T2D.