Animal lifespan is increased by fasting and a reduction of insulin/IGF signaling (IIS), an effect that is conserved from nematodes to humans. Two major "signaling nodes", Forkhead box O1 (FoxO1)- and Target Of Rapamycin Complex 1 (TORC1)-centered, are responsible for the effect of nutrients and IIS on the lifespan. Zaarur et al. recently found that FoxO1 and mTORC1 control the rates of lipolysis in mammalian cells by regulating expression of adipose triglyceride lipase (ATGL). Here, they use the nematode C. elegans to show that ATGL is the common mediator of the fasting and IIS longevity effects.