Like most other cell types, adipocytes express many G protein-coupled receptors (GPCRs). Each GPCR displays a distinct G protein coupling preference, activating either Gs- Gi-, or Gq-type G proteins which are linked to specific signaling pathways. At present, little is known about how activation of these various GPCR/G protein pathways affects glucose homeostasis. Wang et al. used Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) that can only be activated by an exogenously administered drug to elucidate the impact of Gs signaling in adipocytes. In agreement with the report by Caron et al., they found improved glucose homeostasis upon Gs activation.