Weight reduction by lifestyle interventions is possible, but often followed by weight regain. Maurer and colleagues sought to determine predictors of successful maintenance of weight loss. They analyzed the interaction of dorsolateral prefrontal cortex (DLPFC) activity after presentation of food cues and the response of GLP-1 after oral glucose intake in individuals taking part in a weight loss-weight maintenance intervention study over 27 months. The interaction of GLP-1 and DLPFC activity was a predictor for successful body weight regulation. Biomarkers for body weight regulation may be improved by considering neuronal and hormonal processes together since their interaction might be superordinate to each phenotype alone.