Over the past decade, our understanding of human pancreas development has steadily increased. This is partially due to the recent advancements in differentiation of human pluripotent stem cells into pancreatic islet-like clusters. Although this in vitro differentiation system has provided lots of information, it cannot address the impact of tissue morphogenesis on endocrine cell differentiation. Therefore, Bakhti, Scheibner, et al. developed a simple ex vivo 3D cyst culture from pancreatic progenitors, providing a high-resolution modeling system that not only allows for studying pancreas development in a temporal fashion but also enables comparing pancreatic epithelial biology across species and genotypes.