Volume 30 | December 2019

Cover Story

Glucagon-like peptide 1 (GLP-1) is a multifaceted hormone that has diverse metabolic effects. Müller et al. provide a comprehensive overview of the literature on GLP-1, including historical records from the discovery of GLP-1 and its identification as a gastrointestinal insulinotropic hormone, as well as detailed discussion of its synthesis, secretion, and degradation. The receptors for GLP-1 are described, as well as the molecular mechanisms underlying GLP-1-induced insulin secretion.

GLP-1 has a plethora of effects: it influences beta-cell proliferation and apoptosis, glucagon secretion, the cardiovascular system, food intake and body weight, water intake, energy expenditure, gastric emptying, the hypothalamic pituitary adrenal axis, learning and memory, and bone. GLP-1 analogs are already being used for the treatment of diabetes, and GLP-1 based obesity treatments are in the process of clinical evaluation. There is considerable and ongoing effort to further optimize their action profile to improve therapeutic outcome. Overall, the multifaceted nature of GLP-1 action makes it an interesting starting point for the development of treatments for various diseases.

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Jean-Claude Henquin

T.D. Müller, B. Finan, S.R. Bloom, D.D’Alessio, D.J. Drucker, P.R. Flatt, A. Fritsche,F. Gribble, H.J. Grill, J.F. Habener, J.J. Holst, W. Langhans,…

Jessica M. Olsen, Alice Åslund, Muhammad Hamza Bokhari, Dana S. Hutchinson, Tore Bengtsson

Alexandra Milona, Vittoria Massafra, Harmjan Vos, Jyoti Naik, Natalia Artigas, Helen A.B. Paterson, Ingrid T.G.W. Bijsmans, Ellen C.L. Willemsen, Jose…

Judith Giroud-Gerbetant, Magali Joffraud, Maria Pilar Giner, Angelique Cercillieux, Simona Bartova, Mikhail V. Makarov, Rubén Zapata-Pérez, José L.…

Mathilde Mouchiroud, Étienne Camiré, Manal Aldow, Alexandre Caron, Éric Jubinville, Laurie Turcotte, Inés Kaci, Marie-Josée Beaulieu, Christian Roy,…

Katarina Klepac, JuHee Yang, Staffan Hildebrand, Alexander Pfeifer

 

Patrick J. Antonellis, Brian A. Droz, Richard Cosgrove, Libbey S. O'Farrell, Tamer Coskun, James W. Perfield, Steven Bauer, Mark Wade, Tara E.…

Christie M. Penniman, Pablo A. Suarez Beltran, Gourav Bhardwaj, Taylor L. Junck, Jayashree Jena, Kennedy Poro, Michael F. Hirshman, Laurie J.…

Sophie Trefely, Joyce Liu, Katharina Huber, Mary T. Doan, Helen Jiang, Jay Singh, Eliana von Krusenstiern, Anna Bostwick, Peining Xu, Juliane G.…

Richard C. Chang, Kara N. Thomas, Yudhishtar S. Bedi, Michael C. Golding

Isa Kolbe, Brinja Leinweber, Matthias Brandenburger, Henrik Oster

Wei Huang, Nicholas J. Queen, Travis B. McMurphy, Seemaab Ali, Lei Cao

Karthickeyan Chella Krishnan, Simon Sabir, Michaël Shum, Yonghong Meng, Rebeca Acín-Pérez, Jennifer M. Lang, Raquel R. Floyd, Laurent Vergnes, Marcus…

Mostafa Bakhti, Katharina Scheibner, Sophie Tritschler, Aimée Bastidas-Ponce, Marta Tarquis-Medina, Fabian J. Theis, Heiko Lickert

Myriam Abarkan, Julien Gaitan, Fanny Lebreton, Romain Perrier, Manon Jaffredo, Christophe Mulle, Christophe Magnan, Matthieu Raoux, Jochen Lang

Daiane F. Engel, Anna N. Grzyb, Jade de Oliveira, Alexandra Pötzsch, Tara L. Walker, Patricia S. Brocardo, Gerd Kempermann, Andreza F. de Bem

Haiyan Fu, Silvia Liu, Sheldon I. Bastacky, Xiaojie Wang, Xiao-Jun Tian, Dong Zhou

Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen

Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen