The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that nucleates two structurally and functionally distinct complexes, mTORC1 and mTORC2. The available data do not identify a clear or consistent role for adipocyte mTORC1 signaling in systemic lipid homeostasis. Paolella et al. demonstrate that mTORC1 signaling in adipose tissue is critical for the maintenance of plasma lipid homeostasis in the fed state. Lack of mTORC1 in adipocytes increases both lipolysis and circulating triglycerides in fed mice.