With the rising use of bariatric surgery, there is also greater awareness of associated complications, one of which is post-bariatric surgery hypoglycemia (PBH). Episodes of hypoglycemia impair cognition and increase the risk for syncope, cardiac arrhythmias, seizures, coma, and even death. While medication or lifestyle modifications can be used effectively to reduce recurrence in diabetic patients, this is not the case for bariatric surgery patients. Evers, Kim, and colleagues propose that rat models of VSG replicate many aspects of PBH in humans. They found that VSG increases glycemic variability, and in response to a mixed-meal liquid gavage, hypoglycemia is readily detectable. Blockade of GLP-1R signaling prevents falls in the glucose nadir but does not improve glycemic variability.