Volume 58 | April 2022

Cover Story

Cachexia is a wasting syndrome accompanying several chronic diseases, and it is characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. Although this syndrome is most common in pancreatic and gastric cancer, it occurs in many other types of cancers and chronic diseases such as rheumatoid arthritisand chronic renal failure. The underlying etiology of cachexia is multifactorial and is the result of crosstalk between different organs and the release of pro-inflammatory signals from affected peripheral tissues. The onset of cachexia has a profoundly negative impact on quality of life of affected individuals, and cancer cachexia patients have a low tolerance for cancer treatments, further exacerbating mortality. Therefore, a better understanding of the molecular mechanisms behind this condition is required to provide better treatment options that can improve the quality of life and prognosis of patients.

Full text



All Articles

Wenguang Chang, Mengyang Li, Lin Song, Suo Miao, ... Jianxun Wang

Kaiting Ning, Shiqiang Liu, Baoqiang Yang, Rui Wang, ... Huiyun Xu

Christian Huisman, Mason A. Norgard, Peter R. Levasseur, Stephanie M. Krasnow, ... Daniel L. Marks

Miriayi Alimujiang, Jingjing Sun, Shuqing Chen, Ningning Bai, ... Ying Yang

Hyejin Lee, Eunmi Kim, Eun-Ae Shin, Jong Cheol Shon, ... Jung Weon Lee


Ferrol I. Rome, Curtis C. Hughey

Lavinia Boccia, Tito Borner, Misgana Y. Ghidewon, Patricia Kulka, ... Christelle Le Foll

Nnamdi G. Nelson, Lili Wu, Matthew T. Maier, Diana Lam, ... Allison W. Xu

Teemu Martikainen, Fjola Sigurdardottir, Christian Benedict, Torbjørn Omland, Jonathan Cedernaes