Volume 59 | May 2022

Cover Story

The prevalence of obesity and type II diabetes is growing globally at rates indicating that environment rather than genes is the principal driver. Exposures to high-fat diet and toxicants, as well as micronutrient deficiency, can impact our health and that of future generations. Only now are we beginning to identify mechanisms linking these exposures to parental and offspring health. The epigenome refers to the biochemical content associated with DNA that impacts gene expression and chromatin organization. Uncovering how genomic information is organized and regulated through epigenetic processes to control gene expression and cell functions in the next generation is still in a nascent stage.

Full text



All Articles

Rossella Menghini, Lesley Hoyles, Marina Cardellini, Viviana Casagrande, ... Massimo Federici

Yue Qi, Nicola J. Lee, Chi Kin Ip, Ronaldo Enriquez, ... Herbert Herzog

Samuel Furse, Samuel Virtue, Stuart G. Snowden, Antonio Vidal-Puig, ... Albert Koulman

Andrea S. Pereyra, Chien-Te Lin, Daniela Mesa Sanchez, Julia Laskin, ... Jessica M. Ellis

Kimihiro Nishimura, Yukihiro Fujita, Shogo Ida, Tsuyoshi Yanagimachi, ... Hiroshi Maegawa

Anne-Sophie Pepin, Christine Lafleur, Romain Lambrot, Vanessa Dumeaux, Sarah Kimmins


Eva Rial-Pensado, Oscar Freire-Agulleiro, Marcos Ríos, Deng Fu Guo, ... Miguel López

Huan Xu, Zhixiao Liu, Dajun Gao, Peizhang Li, ... Zhong Wang

Bin Jiang, Dongdong Wang, Yunfu Hu, Wenxuan Li, ... Qi Chen

Kate Lee, Sanaz Vakili, Hannah J. Burden, Shannon Adams, ... Peter R. Shepherd