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Nicotinamide adenine dinucleotide (NAD+) is an essential co-substrate for several enzyme classes, such as sirtuins and poly ADP-ribose polymerases (PARPs), that regulate a myriad of signaling pathways governing metabolism, healthy aging, and lifespan extension. The NAD+ salvage pathway is the dominant pathway for NAD+ biosynthesis in mammals. In this pathway, nicotinamide phosphoribosyl transferase (NAMPT) plays a central role. NAMPT protein content in skeletal muscle is higher in athletes compared to sedentary individuals, and positively correlated with mitochondrial function, insulin sensitivity, and oxidative capacity in humans. To further probe the putative salutary effects of increased NAMPT activity, Costford, Brouwers et al. generated a mouse transgenic line that overexpressed NAMPT in skeletal muscle (NamptTg). They reveal a fascinating interaction between elevated NAMPT activity in skeletal muscle and voluntary exercise that manifests as a striking improvement of exercise endurance. Voluntary exercise training elicited a 3-fold higher exercise endurance in NamptTg versus WT mice. The precise molecular mechanism for this effect, however, is still to be identified.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

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Amna Khamis
University of Lille, CNRS, Institute Pasteur de Lille, Lille, France
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