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Past Issue

Volume 18 | December 2018


Commentary
“Let's Stay Together”; GIP and GLP-1 dual agonism in the treatment of metabolic diseaseRichard D. DiMarchi

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Original Research Article
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of conceptTamer Coskun, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister B. Bokvist, Xuewei Cui, Daniel A. Briere, Over Cabrera, William C. Roell, Uma Kuchibhotla, Julie S. Moyers, Charles T. Benson, Ruth E. Gimeno, David A. D'Alessio, Axel Haupt

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Original Research Article
Control of hepatic gluconeogenesis by Argonaute2Xin Yan, Zhen Wang, Christopher A. Bishop, Karolin Weitkunat, Xiao Feng, Marcel Tarbier, Jiankai Luo, Marc R. Friedländer, Ralph Burkhardt, Susanne Klaus, Thomas E. Willnow, Matthew N. Poy

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Original Research Article
Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primatesStephanie R. Wesolowski, Christopher M. Mulligan, Rachel C. Janssen, Peter R. Baker, Bryan C. Bergman, Angelo D'Alessandro, Travis Nemkov, Kenneth N. Maclean, Hua Jiang, Tyler A. Dean, Diana L. Takahashi, Paul Kievit, Carrie E. McCurdy, Kjersti M. Aagaard, Jacob E. Friedman

Abstract | Graphical abstract | PDF



Original Research Article
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesityR. Gerlini, L. Berti, J. Darr, M. Lassi, S. Brandmaier, L. Fritsche, F. Scheid, A. Böhm, A. Königsrainer, H. Grallert, H.U. Häring, M. Hrabě de Angelis, H. Staiger, R. Teperino

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Original Research Article
Activation of estrogen receptor alpha induces beiging of adipocytesRoberta S. Santos, Aaron P. Frank, Luciana A. Fátima, Biff F. Palmer, Orhan K. Öz, Deborah J. Clegg

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Original Research Article
TRPV1 neurons regulate β-cell function in a sex-dependent mannerJoey Bou Karam, Weikang Cai, Rowaida Mohamed, Tianwen Huang, Lingqiong Meng, Erica Paige Homan, Ercument Dirice, C. Ronald Kahn, Abdelfattah El Ouaamari

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Original Research Article
N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditureYukitomo Arao, Katherine J. Hamilton, Sydney L. Lierz, Kenneth S. Korach

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Original Research Article
Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditureGiuseppe Bruschetta, Jung Dae Kim, Sabrina Diano, Li F. Chan

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Original Research Article
Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptorElizabeth M. Rhea, Therese S. Salameh, Sarah Gray, Jingjing Niu, William A. Banks, Jenny Tong

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Original Research Article
Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv miceSteven J. Millership, Simon J. Tunster, Mathew Van de Pette, Agharul I. Choudhury, Elaine E. Irvine, Mark Christian, Amanda G. Fisher, Rosalind M. John, James Scott, Dominic J. Withers

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Original Research Article
Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exerciseZhenyan He, Yong Gao, Amber L. Alhadeff, Carlos M. Castorena, Yiru Huang, Linh Lieu, Sadia Afrin, Jia Sun, J. Nicholas Betley, Hongbo Guo, Kevin W. Williams

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Original Research Article
Endocannabinoid and nitric oxide systems of the hypothalamic paraventricular nucleus mediate effects of NPY on energy expenditureZoltán Péterfi, Imre Farkas, Raphael G.P. Denis, Erzsébet Farkas, Motokazu Uchigashima, Tamás Füzesi, Masahiko Watanabe, Ronald M. Lechan, Zsolt Liposits, Serge Luquet, Csaba Fekete

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Brief Communication
Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory FactorJérémy Amosse, Maëva Durcin, Marine Malloci, Luisa Vergori, Audrey Fleury, Frédéric Gagnadoux, Séverine Dubois, Gilles Simard, Jérôme Boursier, Olivier Hue, M. Carmen Martinez, Ramaroson Andriantsitohaina, Soazig Le Lay

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Brief Communication
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetesDagmar Schumacher, Jakob Morgenstern, Yoko Oguchi, Nadine Volk, Stefan Kopf, Jan Benedikt Groener, Peter Paul Nawroth, Thomas Fleming, Marc Freichel

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Brief Communication
Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiationManoj K. Gupta, Dario F. De Jesus, Sevim Kahraman, Ivan A. Valdez, Farnaz Shamsi, Lian Yi, Adam C. Swensen, Yu-Hua Tseng, Wei-Jun Qian, Rohit N. Kulkarni

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Editorial Board and Credits


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Randy J. Seeley, Henriette Frikke-Schmidt
Department of Surgery, University of Michigan, Ann Arbor, USA
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