Insulinotropic polypeptide (GIP) is a gut-derived hormone that potentiates glucose-dependent insulin secretion via cognate receptors on islet β-cells. It also exerts a wide range of extra-pancreatic actions. Beaudry et al. studied the physiological roles of GIP in brown adipose tissue (BAT) using tissue-specific deletions of the GIP receptor. They found the BAT GIP receptor associated with changes in gene expression, IL-6 expression and secretion, oxygen consumption ex vivo, lipid utilization, the defence of body temperature, and metabolism.