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Autoimmunity, cancer, obesity and diabetes are associated with abnormal cellular bioenergetics in various cell types (reviewed in. The most fundamental parameters of cellular bioenergetics are respiration and anaerobic-like glycolysis, hereafter termed glycolysis. Cellular metabolism controls cell fate decisions and immune cell effector functions and vice versa, cell-intrinsic programs control metabolism.  In addition, changing environments induce the rewiring of redox networks. For instance, germinal center responses, plasma cell differentiation and humoral immunity require oxidative phosphorylation (OxPhos) in B cells, while pre germinal center B cell proliferation depends on pyruvate reduction by lactate dehydrogenase A. In pathologic conditions, such as rheumatoid arthritis (RA), T cells with a short-lived, pro-inflammatory effector phenotype appear in the blood. This correlates with mitochondrial DNA (mtDNA) damage. Hence, identifying immune cell metabolic phenotypes discriminating healthy from pathological conditions may be a key tool for diagnostic purposes. Indeed, alterations in cell metabolism have been linked to disease for a long: Otto Warburg has found that tumor cells produce lactate even under aerobic conditions, a phenomenon that also may take place in rapidly proliferating non-transformed cells or in cells with defects of complex I assembly.

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Current Issue

Manon Duquenne, Eleonora Deligia, Cintia Folgueira, Cyril Bourouh, ... Vincent Prévot

Manvita Mareboina, Elen Deng, Ioannis Mouratidis, Nelson S. Yee, ... Dionysios V. Chartoumpekis

Amée M. Buziau, Maaike H. Oosterveer, Kristiaan Wouters, Trijnie Bos, ... Martijn C.G.J. Brouwers

Ariful Haque Abir, Leonie Weckwerth, Artur Wilhelm, Jana Thomas, ... Dirk Mielenz

W. Staels, C. Berthault, S. Bourgeois, V. Laville, ... R. Scharfmann

Mahmoud Taha, Essam A. Assali, Tsipi Ben-Kasus Nissim, Grace E. Stutzmann, ... Israel Sekler

Önay Veli, Öykü Kaya, Ana Beatriz Varanda, Ximena Hildebrandt, ... Nieves Peltzer

Ye Cao, Masaya Araki, Yoshimi Nakagawa, Luisa Deisen, ... Maximilian Kleinert

Paloma Ruiz-Blázquez, María Fernández-Fernández, Valeria Pistorio, Celia Martinez-Sanchez, ... Anna Moles

R.P. Reynolds, R.R. Fan, A. Tinajero, X. Luo, ... J.K. Elmquist

Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, ... Brijesh K. Singh

Hui Yu, Angelika Chiang, Marcelo Rubinstein, Malcolm J. Low

Margit Wunderlich, Manuel Miller, Bärbel Ritter, Ronan Le Gleut, ... Markus Brielmeier

Articles in Press

Romana Stark, Harry Dempsey, Elizabeth Kleeman, Martina Sassi, ... Zane B. Andrews

Tatiana Lopes, David C.D. Hope, Jose M. Ramos-Pittol, Anna Curtis, ... Bryn M. Owen

Canghai Guan, Xinlei Zou, Chengru Yang, Wujiang Shi, ... Xiangyu Zhong

Ames K. Sutton Hickey, Jordan Becker, Eva O. Karolczak, Andrew Lutas, Michael J. Krashes

Ammar A. Abdelrahman, Porsche V. Sandow, Jing Wang, Zhimin Xu, ... Robert W. Caldwell

Carmen L. Bayly, Xiao-Qing Dai, Cuilan Nian, Paul C. Orban, ... Francis C. Lynn

Nader H. Mahmoudzadeh, Yasaman Heidarian, Jason P. Tourigny, Alexander J. Fitt, ... Jason M. Tennessen

You are what you eat

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