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Glucagon-like peptide 1 (GLP-1) is an important gut derived hormone that enables nutrient assimilation. There are several well-established actions of GLP-1, including stimulation of postprandial insulin secretion from β cells supporting development of GLP-1 medicines for type 2 diabetes (T2D), and reduction of appetite, enabling weight loss and approval of GLP-1-based medicines for the treatment of people with obesity. The expanding actions and improved efficacy of modern GLP-1 receptor agonists (GLP-1RAs) have led to increasing utilization of these medicines for people with T2D and obesity. Moreover, the safety of these medicines has been reinforced by data from cardiovascular outcome trials demonstrating reductions in rates of non-fatal myocardial infarction, non-fatal stroke, cardiovascular death and all-cause mortality.


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You are what you eat

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