Volume 35 | May 2020

Cover Story

Histaminergic neurons are confined to the tuberomammillary nucleus (TMN) in the posterior hypothalamus and provide the sole source of neuronal histamine to the brain.  These neurons are identified based on the expression of histidine decarboxylase (HDC), the enzyme required to convert l-histidine into histamine. HDC neurons form a crucial part of the ascending arousal system and have well-established roles in regulating sleep and wakefulness.


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