Volume 56 | February 2022

Cover Story

Growth differentiation factor 15 (GDF15), formerly known as macrophage inhibitory cytokine-1 (MIC-1), is a cytokine expressed and secreted in response to a variety of stimuli as part of stress and disease processes. Clinical studies demonstrate that GDF15 levels serve as a biological marker for prognosis and diagnosis of certain types of cancers and chronic hyperglycemia. Importantly, exogenous GDF15 administration and increased endogenous GDF15 production (e.g., tumor-derived) suppress feeding and body weight primarily via the induction of nausea, emesis, and malaise.

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Benjamin C. Reiner, Richard C. Crist, Tito Borner, Robert P. Doyle, ... Bart C. De Jonghe