the molecular differences between this fat compared to perirenal fat more distant from sources of norepinephrine. They demonstrate that most of the perirenal fat in adult humans consists of dormant BAT [...] Perirenal fat surrounds the kidney as well as the adrenal gland, which secretes epinephrine and norepinephrine in response to sympathetic activation. Jespersen, Feizi, et al. hypothesized that multilocular

determination of the quantity and location of this new beige fat mass is a challenge. The difference in mitochondrial abundance between WAT and beige fat suggests that an imaging agent able to quantify mitochondrial [...] mitochondrial expression may be ideal for identifying beige fat mass. TSPO-18kDa (TSPO) is a five transmembrane domain protein located on the outer membrane of mitochondria, which may be detected using positron

prolonged high fat feeding. Their findings indicate that murine FAP is not a critical determinant of islet function, glucose homeostasis, weight gain, and the metabolic response to high fat feeding in mice

Huang, Queen, McMurphy, et al. manipulated PTEN expression in an individual fat depot to investigate how PTEN modulates fat depot distribution in adult mouse and discovered a PTEN-leptin-sympathetic signaling

sex-specific effect on fat accumulation in female Lumican knockout mice that coincided with increased inflammation and insulin resistance. Likewise, Lumican overexpression in the visceral fat and liver improved

increased muscle size associated with increased energy expenditure, which mitigated fat gain and metabolic complications of a high fat diet. Furthermore, they identified sex-based differences in AKT2 expression

intermediary. CPT1C knockout (KO) mice are more prone to become obese when chronically fed a high fat diet with a reduced peripheral fatty acid oxidation. Rodríguez-Rodríguez et al. show that the obese [...] adipose tissue thermogenesis. Thus, their data uncover CPT1C as a key factor in the control of brown fat thermogenesis.

Objective A sustained high fat diet in mice mimics many features of human obesity. We used male and female Non-Swiss albino mice to investigate the impact of short and long-term high-fat diet-(HFD)-induced obesity [...] synaptic structural alterations were reversible after switching obese mice from HFD to a standard fat diet (SD). Methods HFD-induced obese and age-matched control mice fed SD were used. We carried out [...] were observed at NMJs of age-matched HFD obese female mice or male mice fed with a standard or low fat diet. Intriguingly, when obese male mice were switched from HFD to a standard diet, receptor density

levels of muscle fat that is dispersed in small lipid droplets in oxidative type I muscle fibers. On the other hand, in the insulin resistant type 2 diabetic state, most of the muscle fat is found in large

adipocyte differentiation and function, as well as their in vivo influence on beige fat and metabolic parameters of mice on a high fat diet. Their results show that AgNPs suppress beige adipocyte development and

Regulatory T cells (Tregs) are key in controlling tissue homeostasis and function including local fat depots, where they can suppress inflammatory processes. It has been previously shown that short-term

factor 4 (ATF4), and ATF5 that regulate expression of stress and apoptosis genes to influence β cell fate decisions during stress.

adipose tissue through a centrally mediated effect. In the brown fat cells, thermogenesis would occur due to activation of the brown-fat-specific uncoupling protein 1 (UCP1). To test this hypothesis, Dittner

expenditure, blunted leptin sensitivity, and hyperphagia in adulthood, resulting in obesity under high fat diet-feeding or associated with aging.

Monocarboxylate transporter isoform 1 (MCT1) haploinsufficient mice (MCT1+/-) exhibit resistance to high-fat diet-induced obesity and associated NAFLD. Carneiro et al. reinforce the concept that AMP-activated