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Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice

Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis

Beige fat is dispensable for the metabolic benefits associated with myostatin deletion

Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding

Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11

PPARγ and PPARα synergize to induce robust browning of white fat in vivo

The disassembly of the neuromuscular synapse in high-fat diet-induced obese male mice

High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus

ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids

Anastasia Tsakmaki, Patricia Fonseca Pedro, Polychronis Pavlidis, Bu’Hussain Hayee, Gavin A. Bewick

A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment

Brown adipose tissue (BAT) is a specialized thermogenic organ that dissipates chemical energy as heat. Brown adipocytes are equipped with uncoupling protein 1 (UCP1). UCP1 catalyzes the net transport

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1

Brown adipose tissue (BAT) is capable of thermogenesis via uncoupling protein 1 (UCP1) and has high expression of sirtuin 3 (SIRT3), a deacetylase in the mitochondria. Much of the acetylation that occ